An estimated 50,000 teachers, 10,000 schools/sites, and 3 million students have participated in the LifeSkills Training program. The duration of implementation varies; some sites have implemented LST for 5 years or longer. LST has been extensively evaluated in more than 35 scientific studies involving more than 330 schools/sites and 26,000 students in suburban, urban, and rural settings.

LST has been used with youth in all 50 states in the United States as well as in the District of Columbia, Puerto Rico, and the Virgin Islands. Outside the United States, it has been used in 39 countries including: